USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: O43464 USC-OGP 2-DE database:  O43464 O43464 General information about the entry View entry in simple text format Entry name HTRA2_HUMAN Primary accession number O43464 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Serine protease HTRA2, mitochondrial; EC=3.4.21.108; AltName: Full=High temperature requirement protein A2; Short=HtrA2; AltName: Full=Omi stress-regulated endoprotease; AltName: Full=Serine protease 25; AltName: Full=Serine proteinase OMI; Flags: Precursor;. Gene name Name=HTRA2 Synonyms=OMI, PRSS25 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0737: pI=5.89; Mw=35605 SPOT OGP-0739: pI=5.96; Mw=35428 Cross-references UniProtKB/Swiss-Prot O43464; HTRA2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name HTRA2_HUMAN Primary accession number O43464 Secondary accession number(s) Q9HBZ4 Q9P0Y3 Q9P0Y4 Sequence was last modified on  May 1, 2000 (version 2) Annotations were last modified on  March 15, 2017 (version 185) Name and origin of the protein Description RecName: Full=Serine protease HTRA2, mitochondrial; EC=3.4.21.108; AltName: Full=High temperature requirement protein A2; Short=HtrA2; AltName: Full=Omi stress-regulated endoprotease; AltName: Full=Serine protease 25; AltName: Full=Serine proteinase OMI; Flags: Precursor; Gene name Name=HTRA2 Synonyms=OMI, PRSS25 Encoded on Name=HTRA2; Synonyms=OMI, PRSS25 Keywords 3D-structure; Alternative splicing; Apoptosis; Autocatalytic cleavage; Complete proteome; Direct protein sequencing; Disease mutation; Hydrolase; Membrane; Mitochondrion; Neurodegeneration; Parkinson disease; Parkinsonism; Polymorphism; Protease; Reference proteome; Serine protease; Transit peptide; Transmembrane; Transmembrane helix; Zymogen. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AF020760; AAB94569.2; -; mRNA EMBL AF141305; AAF66596.1; -; mRNA EMBL AF141306; AAF66597.1; -; mRNA EMBL AF141307; AAF66598.1; -; mRNA EMBL AF184911; AAG13126.1; -; mRNA EMBL AC006544; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC000096; AAH00096.1; -; mRNA CCDS CCDS1951.1; -. [O43464-1]; . CCDS CCDS1952.1; -. [O43464-2]; . RefSeq NP_001308656.1; NM_001321727.1. [O43464-3]; . RefSeq NP_037379.1; NM_013247.4. [O43464-1]; . RefSeq NP_659540.1; NM_145074.2. [O43464-2]; . UniGene Hs.469045; -; . UniGene Hs.744841; -; . PDB 1LCY; X-ray; 2.00 A; A=134-458 PDB 2PZD; X-ray; 2.75 A; A/B=359-458 PDB 5FHT; X-ray; 1.95 A; A=134-458 PDBsum 1LCY; -; . PDBsum 2PZD; -; . PDBsum 5FHT; -; . DisProt DP00315; -; . ProteinModelPortal O43464; -; . SMR O43464; -; . BioGrid 118165; 64; . IntAct O43464; 42; . MINT MINT-216075; -; . STRING 9606.ENSP00000258080; -; . MEROPS S01.278; -; . iPTMnet O43464; -; . PhosphoSitePlus O43464; -; . BioMuta HTRA2; -; . OGP O43464; -; . EPD O43464; -; . MaxQB O43464; -; . PaxDb O43464; -; . PeptideAtlas O43464; -; . PRIDE O43464; -; . TopDownProteomics O43464-2; -. [O43464-2]; . DNASU 27429; -; . Ensembl ENST00000258080; ENSP00000258080; ENSG00000115317. [O43464-1]; . Ensembl ENST00000352222; ENSP00000312893; ENSG00000115317. [O43464-2]; . GeneID 27429; -; . KEGG hsa:27429; -; . UCSC uc002smi.2; human. [O43464-1]; . CTD 27429; -; . DisGeNET 27429; -; . GeneCards HTRA2; -; . GeneReviews HTRA2; -; . HGNC HGNC:14348; HTRA2; . HPA CAB004004; -; . HPA HPA006602; -; . HPA HPA027366; -; . MalaCards HTRA2; -; . MIM 168600; phenotype; . MIM 606441; gene; . MIM 610297; phenotype; . neXtProt NX_O43464; -; . OpenTargets ENSG00000115317; -; . Orphanet 2828; Young adult-onset Parkinsonism; . PharmGKB PA33836; -; . eggNOG KOG1320; Eukaryota; . eggNOG COG0265; LUCA; . GeneTree ENSGT00510000046315; -; . HOGENOM HOG000223641; -; . HOVERGEN HBG052044; -; . InParanoid O43464; -; . KO K08669; -; . OMA EINGQAT; -; . OrthoDB EOG091G0LXR; -; . PhylomeDB O43464; -; . TreeFam TF323480; -; . BRENDA 3.4.21.108; 2681; . SIGNOR O43464; -; . ChiTaRS HTRA2; human; . EvolutionaryTrace O43464; -; . GeneWiki HtrA_serine_peptidase_2; -; . GenomeRNAi 27429; -; . PMAP-CutDB O43464; -; . PRO PR:O43464; -; . Proteomes UP000005640; Chromosome 2; . Bgee ENSG00000115317; -; . CleanEx HS_HTRA2; -; . ExpressionAtlas O43464; baseline and differential; . Genevisible O43464; HS; . GO GO:0035631; C:CD40 receptor complex; ISS:BHF-UCL; . GO GO:0000785; C:chromatin; IDA:ParkinsonsUK-UCL; . GO GO:0009898; C:cytoplasmic side of plasma membrane; ISS:BHF-UCL; . GO GO:0005856; C:cytoskeleton; IDA:ParkinsonsUK-UCL; . GO GO:0005829; C:cytosol; IDA:ParkinsonsUK-UCL; . GO GO:0005783; C:endoplasmic reticulum; NAS:UniProtKB; . GO GO:0005789; C:endoplasmic reticulum membrane; TAS:UniProtKB; . GO GO:0016020; C:membrane; IDA:ParkinsonsUK-UCL; . GO GO:0005758; C:mitochondrial intermembrane space; IDA:MGI; . GO GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell; . GO GO:0005739; C:mitochondrion; IDA:UniProtKB; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0008233; F:peptidase activity; IDA:UniProtKB; . GO GO:0004252; F:serine-type endopeptidase activity; IMP:UniProtKB; . GO GO:0008236; F:serine-type peptidase activity; IDA:UniProtKB; . GO GO:0051082; F:unfolded protein binding; NAS:UniProtKB; . GO GO:0007628; P:adult walking behavior; IEA:Ensembl; . GO GO:0007568; P:aging; IEA:Ensembl; . GO GO:0044257; P:cellular protein catabolic process; IDA:ParkinsonsUK-UCL; . GO GO:0071363; P:cellular response to growth factor stimulus; IMP:UniProtKB; . GO GO:0034605; P:cellular response to heat; IDA:UniProtKB; . GO GO:0035458; P:cellular response to interferon-beta; IDA:ParkinsonsUK-UCL; . GO GO:0034599; P:cellular response to oxidative stress; IMP:ParkinsonsUK-UCL; . GO GO:0071300; P:cellular response to retinoic acid; IDA:ParkinsonsUK-UCL; . GO GO:0006672; P:ceramide metabolic process; IEA:Ensembl; . GO GO:0097194; P:execution phase of apoptosis; TAS:UniProtKB; . GO GO:0030900; P:forebrain development; IEA:Ensembl; . GO GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IMP:ParkinsonsUK-UCL; . GO GO:0007005; P:mitochondrion organization; IEA:Ensembl; . GO GO:0045786; P:negative regulation of cell cycle; TAS:UniProtKB; . GO GO:1904924; P:negative regulation of mitophagy in response to mitochondrial depolarization; IEA:Ensembl; . GO GO:1901215; P:negative regulation of neuron death; TAS:ParkinsonsUK-UCL; . GO GO:1902176; P:negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; NAS:ParkinsonsUK-UCL; . GO GO:0048666; P:neuron development; IEA:Ensembl; . GO GO:0019742; P:pentacyclic triterpenoid metabolic process; IEA:Ensembl; . GO GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB; . GO GO:0010942; P:positive regulation of cell death; IDA:UniProtKB; . GO GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB; . GO GO:2001269; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IMP:ParkinsonsUK-UCL; . GO GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IMP:UniProtKB; . GO GO:0010822; P:positive regulation of mitochondrion organization; IMP:ParkinsonsUK-UCL; . GO GO:1903955; P:positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL; . GO GO:0016540; P:protein autoprocessing; TAS:ParkinsonsUK-UCL; . GO GO:0006508; P:proteolysis; IMP:UniProtKB; . GO GO:1903146; P:regulation of mitophagy; TAS:ParkinsonsUK-UCL; . GO GO:0040014; P:regulation of multicellular organism growth; IEA:Ensembl; . GO GO:0009635; P:response to herbicide; IEA:Ensembl; . Gene3D 2.30.42.10; -; 1; . InterPro IPR001478; PDZ; . InterPro IPR009003; Peptidase_S1_PA; . InterPro IPR001940; Peptidase_S1C; . Pfam PF13180; PDZ_2; 1; . PRINTS PR00834; PROTEASES2C; . SMART SM00228; PDZ; 1; . SUPFAM SSF50156; SSF50156; 1; . SUPFAM SSF50494; SSF50494; 1; . PROSITE PS50106; PDZ; 1; .

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